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History of Cordyceps

Cordyceps is a genus of ascomycete fungi (sac fungi) that includes about 400 species.Most Cordyceps species are endoparasitoids, parasitic mainly on insects and other arthropods (they are thus entomopathogenic fungi); a few are parasitic on other fungi. The generic name Cordyceps is derived from the Greek word, meaning “club”, and the Greek word , meaning “head”. The genus has a           worldwide distribution and most of the approximately 400 species. Cordyceps species are particularly abundant and diverse in humid temperate and tropical forests.Cordyceps has been found mainly in North America, Europe and Asia ( Nepal, China, Japan, Bhutan, Korea, Vietnam, an Thailand). . In India, it is prominently found in subalpine regions of grassy lands of Himalayas commonly known as “Keera Ghas” or “Keera Jadi”. Recently it has been reported from Sutol and Kanol villages of Chamoli district of Uttarakhand4. The ethnopharmacological use of Cordyceps sinensis has been reported from western Nepal for the cure of different diseases like diarrhea, headache, cough, rheumatism, liver disease, etc. This herb is also referred as “Himalayan Viagra” or “Himalayan Gold” due to its broad clinical and commercial value7. Cordyceps requires specific set of conditions for its growth and has small size; therefore, the large-scale collection of this mushroom is a daunting task. However, people within the age group 15–65 years including men, women, young boys and girls are the main collectors of this fungus and price for 1 kg of wild-collected mushroom in the market of Nepal varies from 30,000 to 60,000 Nepali Rupees while in India it costs about Rupees 100,000 6. Past 5 years have seen tremendous exploitation of Cordyceps which has significantly reduced its wild occurrence.

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Introduction of Cordyceps Militaris







Cordyceps have a history of medicinal use spanning millennia in parts of Asia .
The Cordyceps has been derived from two Latin words, i.e., cord and ceps meaning club and head, respectively. Cordyceps militaris belongs to the phylum Ascomycota classified in the order hypocreales, as spores are produced internally inside a sac, called ascus . It is an entomopathogenic fungus having an annual appearance which often grows parasitically on lepidopteron larvae and pupae of insects and spiders. It normally inhabits on the surface of insects pupae in winters and leading to the formation of fruiting body in summers justifying its name as “winter-worm summer-grass”. There have been a variety of pharmacologically active compounds (e.g., Cordycepin) reported from Cordyceps sp. Cordycepin has received much attention due to its broad-spectrum biological activity. It is known to interfere with various biochemical and molecular processes including purine biosynthesis . Cordyceps has been included as one of the growing numbers of fungal traditional Chinese medicine (FTCM) used as cures for modern diseases with many products available commercially. Due to recent advancements in pharmaceutical biotechniques, it is possible to isolate bioactive compounds from Cordyceps and make it available in powder as well as in capsular form. Cordyceps and its product have remarkable clinical health effects including action on hepatic, renal, cardiovascular, respiratory, nervous, sexual, immunological systems, besides having anti-cancer, anti-oxidant, anti-inflammatory and anti-microbial activities >. the active principles of C. militaris are beneficial to act anti-aging, anti-tumour/ anti-leukemic, anti-proliferative, anti-metastatic anti-bacterial, anti-viral, anti-fungal, anti-protozoal, insecticidal, larvicidal, anti-fibrotic, steroidogenic, hypoglacaemic, hypolipidaemic, anti-angiogenetic, anti-diabetic, anti-HIV, anti-malarial, anti-fatigue, neuroprotective, liver-protective, as well as pneumo-protective, let alone their other synergistic activities, which let it be marketable in the western countries as over-the-counter medicine.

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Cordyceps Militaris as the protector of the respiratory system

Cordyceps Militaris as the protector of the respiratory system

As per traditional Chinese medicine, Cordyceps Militaris has been talked about as the protector of the human respiratory system since more than a thousand years. [1] In his book, L. Ganxhon describes the ability of the extract from Cordyceps Militaris to reduce symptoms related to asthma, COPD, pneumonia, phlegm, chronic bronchitis and other respiratory troubles. It also displayed the capability to relax bronchial walls and was able to improve oxygen utilizing efficiency of humans. [2] Similar positive treatments have also been done on humans by Zhu.

Cordyceps Militaris is extremely useful for tracheal contractions and is able to generate a higher degree of airflow to the lungs than earlier, which is especially helpful for asthmatic patients.

[3] Another clinical study with 50 asthma patients showed how a group treated with Cordyceps Militaris showcased an improvement of 81.3% rate within just 5 days, in comparison to 61% and an average of 9 days for the group treated with regular antihistamines.

[4] Apart from the above, when mice fed on the mushroom and were placed in an extremely low oxygen environment, it was found that they could utilize oxygen more efficiently (30–50% increase), tolerate acidosis as well as hypoxia (unavailability of oxygen), and were able to survive 2–3 times more than the control group.

References

[1] Ganxhon, L et al. The essentials of traditional Chinese herbal medicine (5th edition). USA: Foreign Language Press, 2003

[2] Zhu, J et al. The Scientific Rediscovery of an Ancient Chinese Herbal Medicine: Cordycep Militaris The Journal Of Alternative And Complementary Medicine [part 1] Volume 4, Number 3, 1998, pp. 289—303 [part 2] Volume 4, Number 4, 1998, pp. 429 – 457

[3] Halpern, G. Cordycep Militaris, Chinas healing mushroom. Avery Publishing 1999: 63-70.

[4] Talbott, SM. A guide to understanding dietary supplements. New York: Haworth Press, 2003

 

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Cordyceps Militaris as an immunity booster

Cordyceps Militaris as an immunity booster

The immune system is one that prevents the body from falling sick, thereby defending it against a number of bacterial, viral and protozoal infections. Sometimes even cancerous cells may appear as bacterial infections after mutation.

The body’s first line of defense is formed by the white blood cells (WBCs) against different kinds of illnesses and infections. [1] Scientist John Holliday suggested in the Encyclopedia of dietary supplements that Cordyceps Militaris is able to increase the number of WBCs in the body. Due to this very quality, the mushroom is frequently recommended as an energy booster during recovery periods from operations.

It was published in the Chinese Journal of Integrated Traditional Western Medicine that Cordyceps Militaris improves immunity(immunity booster) in both healthy persons as well as those suffering from leukemia. [2] Experiments displayed WBC count to increase by 74% amongst the healthy samples and 400% among the leukemia patients.

[3] A book titled “Cordyceps Militaris: China’s Healing Mushroom” tells about several immune-boosting(immunity booster) effects of this mushroom, along with an increase in the number of NK cells, macrophages, WBCs, and T-helper cells. All these cells boost cellular immunity against fungal and viral infections, apart from others as well.

References

[1] Holliday, J et al. Encyclopedia of dietary supplements. Dekker Encyclopedias, Taylor and Francis Publishing, 2005

[2] Talbott, SM. A guide to understanding dietary supplements. New York: Haworth Press, 2003

[3] Halpern, G. Cordycep Militaris: China’s healing mushroom, Avery Publishing Group, New York, 1999

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Save yourself from cancer with Cordyceps Militaris

Save yourself from cancer with Cordyceps Militaris

Traditional Asian medicine has made use of Cordyceps Militaris for a number of years. [1] An anti-cancer effect has been found in the extract of this fungus. It has been tested on cancerous RKO, which is a human colorectal cell line.

Results of the above experiment stated how RKO cells were susceptible to the ethanol extract from Cordyceps Militaris and growth of the tumour from RKO cells had also been delayed significantly. It showed that the ethanol extract of the mushroom was cytotoxic to RKO cells and inhibited the tumour’s growth. This anti-tumour effect was then linked with mitochondrial apoptosis and cell cycle arrest. [2] As per another experiment, it was also seen that Cordyceps Militaris became responsible for deaths of tumour cells by the caspase-dependent mitochondrial pathway in MCF-7 and HepG2 cells.

Cordycepin, often recognized as the most bioactive compound within Cordyceps Militaris, also plays ant- metastatic and anti-tumour roles. This form of alternative medicine finds widespread application in prevention and treatment of cancer. Cordycepin is able to induce apoptosis, show antiproliferative effects, and also have an antiangiogenic effect on human cells, other than targeting cancer stem cells (CSCs).

[3] Studies have also shown that Cordyceps Militaris is able to bring down the growth of cancerous cells within sarcoma S180, Erlich’s ascites carcinoma and MA737 cancer of the breast. Cells in the body are meant to grow and divide in a way that overall health remains constant. Cells that become old or get damaged are replaced by new cells, and tumours tend to form when this division becomes uncontrollable.

References

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491205/

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878560/

[3] Ganxhon, L et al. The essentials of traditional Chinese herbal medicine (5th edition). USA: Foreign Language Press, 2003

 

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Sexual benefits of Cordyceps Militaris


Sexual benefits of Cordyceps Militaris

As per traditional Chinese medicine, Cordyceps Militaris has been used as a remedy for sexual dysfunction over many years. It is also capable of reducing body fatigue or upon culmination of a long disease. [1] There is much data on how the mushroom affected mice and displayed steroid-like effects on sex. Not just mice, but even humans showed changes upon consumption of Cordyceps Militaris.

Clinical trials on humans that were published in the Journal of Alternative and Complimentary Medicine also indicated how sexual activity in humans was made more effective with the administration of Cordyceps Militaris . This was either by acting on the sexual organs or sex hormones. As an example, three separate studies were carried out on 756 persons with subdued sex drive, who were given either 3g of the medicinal mushroom or a placebo for more than 40 days. [1] Results of the above studies indicated that 64.8% of Cordyceps Militaris users reported visible improvement in sexual functions, in comparison to 23.8% of the placebo group.

One of the healthiest ways to increase libido is to practice naturopathy. Though Cordyceps can obviously be used for a better sex drive and erectile functions as it helps in reducing chronic stress, you must always consult your physician before. There are other natural agents to improve sex drive as well, such as:

  • Licorice
  • Ashwaganda
  • Siberian ginseng
  • Relora

References

[1] Zhu, J. et al. The Scientific Rediscovery of an Ancient Chinese Herbal Medicine: Cordycep Militaris The Journal Of Alternative And Complementary Medicine [part 1] Volume 4, Number 3, 1998, pp. 289—303 [part 2] Volume 4, Number 4, 1998, pp. 429 – 457

References

[1] (Holliday, J. et al. On the Trial of The Yak Ancient Cordycep Militaris in the Modern World. 2004)